Nonprofit · Curing Genetic Disease

Framing the gene editing problem. Accelerating the cures.

Genoma Institute is a nonprofit dedicated to curing genetic disease — building the benchmarks, research, and public understanding that gene editing needs to reach the people waiting on it.

1 in 10
people affected by a genetic disease
400M
suffer globally from a rare disease
95%
of rare diseases lack an FDA-approved treatment
10,000+
known genetic disorders exist
Source: GlobalGenes.org · OMIM 2025
The Bottleneck

We have the tools. We're flying blind.

46 approved gene therapies exist today — covering less than 1% of the 10,000+ known genetic disorders. There's no shared roadmap, no agreed benchmarks, no real way to compare the tools we already have. The bottleneck isn't the absence of gene editing technology — it's the absence of a framework to evaluate it. That's the gap Genoma exists to close.

Three Pillars. One Mission.

How we close the gap.

01

CALI Competition

Critical Assessment of Large Cargo Insertion

A biennial, blind, unbiased competition — the Olympics of gene editing. Benchmarks that let academia and industry compete, compare, and learn.

02

Research Lab

Mitochondrial Gene Therapy

A focused nonprofit lab developing gene therapies for mitochondrial DNA diseases — tackling age-related and rare disorders no one else is chasing.

03

State of the Genome

Public Science Communication

A newsletter, podcast, and forum creating a trusted, structured space for public discourse on gene editing, AI in biology, and what it means for humanity.

History Shows How This Gets Solved

In every major scientific field, the breakthrough came after someone framed the problem with an open, unbiased benchmark.

Speech Recognition → benchmark → breakthrough
Chess → benchmark → breakthrough
Object Classification → benchmark → breakthrough
Protein Folding → benchmark → AlphaFold
Gene Editing → ?

Gene editing has the tool. Genoma is building the benchmark.

Partner With Us

Help fund the first open benchmark in gene therapy.

Your support funds the inaugural CALI competition — the first open benchmark in gene therapy since CASP transformed protein folding.

Founding Partner · $500K+ Program Partner · $100–500K Community Partner · up to $100K
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